Application of an R-group search technique in the molecular design of dipeptidyl boronic acid proteasome inhibitors
In this work, a 3D-QSAR model involving for 40 dipeptidyl boronic acid proteasome inhibitors was built Sujihiki Knives based on Topomer CoMFA.The multiple correlation coefficient of fitting, cross-validation and external validation were 0.908, 0.647 and 0.703, respectively.The results indicated that the obtained Topomer CoMFA model has not only the