APPLICATION OF AN R-GROUP SEARCH TECHNIQUE IN THE MOLECULAR DESIGN OF DIPEPTIDYL BORONIC ACID PROTEASOME INHIBITORS

Application of an R-group search technique in the molecular design of dipeptidyl boronic acid proteasome inhibitors

In this work, a 3D-QSAR model involving for 40 dipeptidyl boronic acid proteasome inhibitors was built Sujihiki Knives based on Topomer CoMFA.The multiple correlation coefficient of fitting, cross-validation and external validation were 0.908, 0.647 and 0.703, respectively.The results indicated that the obtained Topomer CoMFA model has not only the

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Towards a web-based GIS for teaching geo-informatics at under-graduate level in developing countries: a case study of Iran

In developing countries, the number of experts and students in geo-informatics domain are very limited compared to experts and students of sciences that could benefit from geo-informatics.In this research, we study the possibility of providing an online education system for teaching geo-informatics at under-graduate level.The hypothesis is that in

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Kinetic arrest during the drying of cellulose nanocrystal films from aqueous suspensions analogous to the freezing of thermal motions

Abstract A comprehensive understanding of controlling the iridescence of cellulose films by manipulating the alignment and helical pitch of cellulose nanocrystals (CNCs) is required to advance cellulose photonics and its optoelectronic applications.Aqueous suspensions of CNCs exhibit a cholesteric liquid crystal (LC) Sujihiki Knives phase with stru

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